6533b7d8fe1ef96bd126a503
RESEARCH PRODUCT
Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling
Shih-han LinChi-kuang YaoYu Chen TsaiGert O. PflugfelderStefan GrimmFred EichingerJu-lan ChaoY. Henry SunJie ShenChih-hsuan ChangShih-chin WangTheoni MichalopoulouKerstin Hofmeyersubject
genetic structuresScienceNerve Tissue ProteinsEyeTranscription (biology)ddc:570AnimalsDrosophila ProteinsReceptorTranscription factorCell ProliferationJanus KinasesGeneticsMultidisciplinarybiologyCell growthQRbiology.organism_classificationCell biologySTAT Transcription FactorsDrosophila melanogasterEye developmentMedicineDrosophila melanogasterJanus kinaseT-Box Domain ProteinsDrosophila ProteinResearch ArticleTranscription Factorsdescription
Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-03-01 |