6533b7d8fe1ef96bd126a9ab

RESEARCH PRODUCT

HEAT SHOCK PROTEINS AND AUTOIMMUNE SYSTEM ACTIVATION IN IBD: ARTICULAR MANIFESTATIONS AND THE EPIDEMIOLOGICAL FREQUENCY IN ORTHPEDICS

G. TomaselloM. D'arienzoA. Lo MonteG. MargiottaA. D'arienzoP. DamianiF. AccardoA. Sanfilippo

subject

IBD Intestinal Bowel Disease Microbiota Arthritis Heat Shock Proteins HSPSettore MED/18 - Chirurgia GeneraleSettore MED/09 - Medicina InternaSettore MED/33 - Malattie Apparato Locomotore

description

clinical evidence suggest that arthritis is one of the complications of inflammatori bowel disease (IBD) of which the etiological causes are still not completely understood. Among the possible explanations the most probable theory is poor regulation of the intestinal immune system, which causes a cross-like immune reactivity against the resident micro flora. Arthritis is these subjects involves different joints and is asymmetric, with greater involvement of the large joints of the lower limbs. Joints may also be involved with the spinal forms of sacroileitis and ankilosing spondylitis. This clinical evidence explains the existence of Lesnioski-Crohn's disease, a variant of IBD in which patients have bone joint problems that may also be the primary manifestations of the disease.

yearjournalcountryeditionlanguage
2013-05-01
http://hdl.handle.net/10447/76942