6533b7d8fe1ef96bd126ab2e

RESEARCH PRODUCT

Immunohistochemical analysis of the patterns of p53 and PCNA expression in odontogenic cystic lesions

Márcia Gaiger De OliveiraIsabel Da Silva LauxenAnna Cecília Moraes ChavesPantelis Varvaki RadosManoel Sant'ana Filho

subject

stomatognathic diseasesOdontogenic tumorsOdontogenic cystsUNESCO::CIENCIAS MÉDICASP53 proteinPCNAPatologia bucal:CIENCIAS MÉDICAS [UNESCO]CistosImmunohistochemistry

description

Objective: the role of p53 expression in odontogenic lesions has not been fully determined, but has been associated with cell proliferation. The purpose of this study was to analyze p53 and proliferating cell nuclear antigen (PCNA) expression in 4 different odontogenic lesions. Design: expression of p53 and PCNA was analyzed in radicular and dentigerous cysts, odontogenic keratocysts, and calcifying odontogenic cysts (Gorlin cysts) using monoclonal antibodies for detection of p53 and PCNA. Results: PCNA expression was significantly greater in the basal layer of radicular cysts and in the suprabasal layer of odontogenic keratocysts; the percentage of p53 positive cells was significantly greater in the suprabasal layer of odontogenic keratocysts. Conclusions: The patterns of p53 and PCNA expression in dentigerous and radicular cysts were similar although the two lesions are of different origin. In odontogenic keratocysts and Gorlin cysts, results indicate a different pattern of tumor growth.

yearjournalcountryeditionlanguage
2008-01-01
http://hdl.handle.net/10550/60787