Remarkable effect of lithium bromide in the enantioselective protonation with α-sulfinyl alcohols

6533b7d8fe1ef96bd126aca0

RESEARCH PRODUCT

Remarkable effect of lithium bromide in the enantioselective protonation with α-sulfinyl alcohols

Pedro Aleman Luis R. Domingo Gregorio Asensio Mercedes Medio-simón

subject

chemistry.chemical_compound chemistry Lithium bromide Organic Chemistry Drug Discovery Tetralone Enantioselective synthesis Organic chemistry Protonation Biochemistry

description

Abstract The favourable effect of lithium bromide enhancing the facial enantioselectivity in the protonation of methyl tetralone enolate with α-sulfinyl alcohols is described. Theoretical calculations allow to propose a model to explain the stereochemical course of the protonation reaction.

year	journal	country	edition	language
1998-05-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(98)00469-9

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