6533b7d8fe1ef96bd126ad2b

RESEARCH PRODUCT

In vitro degradation of porous PLLA/pearl powder composite scaffolds

Qianli HuangWerner E.g. MüllerQingling FengYuhong LiuArne Kienzle

subject

Time FactorsMaterials scienceAbsorption of waterCompressive StrengthScanning electron microscopePolyestersComposite numberBioengineeringBuffersAbsorptionCalcium CarbonateBiomaterialsGel permeation chromatographyHydrolysischemistry.chemical_compoundDifferential scanning calorimetryVateriteAnimalsTransition TemperatureComposite materialLactideCalorimetry Differential ScanningTissue ScaffoldsWaterHydrogen-Ion ConcentrationMolecular WeightSolutionsChemical engineeringchemistryMechanics of MaterialsMicroscopy Electron ScanningCalciumPowdersPorosity

description

Abstract The in vitro degradation behavior of poly- l -lactide (PLLA), PLLA/aragonite pearl powder and PLLA/vaterite pearl powder scaffolds was investigated. The scaffolds were soaked in phosphate buffer solution (PBS) up to 200 days. Scanning electron microscopy (SEM), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) were used to observe any degradation of the scaffolds. Degradation behaviors such as changes in pH, porosity, bulk density, water absorption, weight loss and mechanical properties were discussed. The results show that a gradual increase of the pH in composite scaffolds can decrease the rate of hydrolysis of PLLA. PLLA/vaterite and PLLA/aragonite scaffolds have a similar degradation behavior but a slower rate of degradation than PLLA.

yearjournalcountryeditionlanguage
2013-10-22Materials Science and Engineering: C
https://doi.org/10.1016/j.msec.2014.02.007