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RESEARCH PRODUCT

Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis

Luisa AgnelloMatteo VidaliBruna Lo SassoRosaria Vincenza GiglioCaterina Maria GambinoConcetta ScazzoneAnna Maria CiaccioGiulia BivonaMarcello Ciaccio

subject

Intensive Care UnitsSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicascreeningSepsisBiochemistry (medical)Clinical Biochemistrymonocyte distribution (MDW)biomarkerHumansGeneral MedicineEmergency Service HospitalBiomarkersMonocytes

description

Abstract Objectives Monocyte distribution has recently emerged as a promising biomarker of sepsis, especially in acute setting, such as Emergency Department and Intensive Care Unit. This study aimed to evaluate the accuracy of monocyte distribution width (MDW) for early detecting patients with sepsis by performing a systemic review and meta-analysis of published studies. Methods Relevant publications were identified by a systematic literature search on PubMed and Google Scholar from inception to September 07, 2021. Studies were divided into two groups based on the sepsis criteria applied, namely sepsis-2 or sepsis-3. Results Ten studies including 9,475 individuals, of whom 1,370 with sepsis (742 according Sepsis-2 and 628 according to Sepsis-3), met the inclusion criteria for our meta-analysis. The pooled sensitivity and specificity were 0.789 and 0.777 for Sepsis-2 criteria, 0.838 and 0.704 for Sepsis-3 criteria. Conclusions MDW represents a reliable biomarker for sepsis screening.

yearjournalcountryeditionlanguage
2022-02-15Clinical Chemistry and Laboratory Medicine (CCLM)
https://doi.org/10.1515/cclm-2021-1331