Cell-Free Coelomic Fluid Extracts of the Sea Urchin Arbacia lixula Impair Mitochondrial Potential and Cell Cycle Distribution and Stimulate Reactive Oxygen Species Production and Autophagic Activity in Triple-Negative MDA-MB231 Breast Cancer Cells

6533b7d8fe1ef96bd126af4d

RESEARCH PRODUCT

Cell-Free Coelomic Fluid Extracts of the Sea Urchin Arbacia lixula Impair Mitochondrial Potential and Cell Cycle Distribution and Stimulate Reactive Oxygen Species Production and Autophagic Activity in Triple-Negative MDA-MB231 Breast Cancer Cells

Dalia Maria Lucia Asaro Mirella Vazzana Valentina Lazzara Debora Ragona Federica Affranchi Claudio Luparello Vincenzo Arizza

subject

Cell Settore BIO/05 - Zoologia Ocean Engineering 03 medical and health sciences lcsh:Oceanography 0302 clinical medicine breast cancer lcsh:VM1-989 biology.animal medicine Viability assay lcsh:GC1-1581 Settore BIO/06 - Anatomia Comparata E Citologia Arbacia lixula Sea urchin 030304 developmental biology Water Science and Technology Civil and Structural Engineering chemistry.chemical_classification 0303 health sciences Reactive oxygen species biology lcsh:Naval architecture. Shipbuilding. Marine engineering Cell cycle biology.organism_classification echinoderm medicine.anatomical_structure chemistry Apoptosis 030220 oncology & carcinogenesis Cancer research cytotoxicity Breast carcinoma

description

Triple-negative breast cancer (TNBC) is a highly malignant tumor histotype which lacks effective targeted therapies, thereby being considered as the most aggressive form of breast carcinoma. To identify novel compounds which could counteract TNBC cell growth, we explored the in vitro effects of crude extracts and &lt

year	journal	country	edition	language
2020-04-07	Journal of Marine Science and Engineering

10.3390/jmse8040261 https://www.mdpi.com/2077-1312/8/4/261

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