6533b7d8fe1ef96bd126af7e
RESEARCH PRODUCT
Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline
Virginia SpanòGirolamo CirrincionePatrizia DianaPaola BarrajaAnna Carbonesubject
Antitumor activityAnnulationPyrimidineStereochemistryOrganic ChemistryIsoindole building blocksAntiproliferative activityRing (chemistry)Biochemistry4-h ]quinazolinesSettore CHIM/08 - Chimica FarmaceuticaIsoindole building blockchemistry.chemical_compoundchemistryPyrimidine annelationDrug DiscoveryPyrrolo[3; 4-h ]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelationQuinazolineMoietyPyrrolo[3Pyrrolo[34-h ]quinazolineIsoindoledescription
Abstract A convenient synthesis of the pyrrolo[3,4- h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-09-01 |