6533b7d8fe1ef96bd126aff4

RESEARCH PRODUCT

Sex differences in neuromuscular disorders

Claudia VinciguerraSalvatore IaconoLiliana BevilacquaAnnamaria LandolfiGiuseppe PiscosquitoFederica GinanneschiGiuseppe SchiròVincenzo Di StefanoFilippo BrighinaPaolo BaroneCarmela Rita Balistreri

subject

AgingGenetic factorGenetic factorsNeuromuscular Disorders Sex Gender Hormones Genetic factorsNeuromuscular DisordersGenderSexNeuromuscular DisorderHormoneHormonesDevelopmental Biology

description

: The prevalence, onset, pathophysiology, and clinical course of many neuromuscular disorders (NMDs) may significantly differ between males and females. Some NMDs are more frequently observed in females, and characterized to show a higher grade of severity during or after the pregnancy. Meanwhile, others tend to have an earlier onset in males and exhibit a more variable progression. Prevalently, sex differences in NMDs have a familiar character given from genetic inheritance. However, they may also influence clinical presentation and disease severity of acquired NMD forms, and are represented by both hormonal and genetic factors. Consequently, to shed light on the distinctive role of biological factors in the different clinical phenotypes, we summarize in this review the sex related differences and their distinctive biological roles emerging from the current literature in both acquired and inherited NMDs.

10.1016/j.mad.2023.111793https://hdl.handle.net/11365/1226795