6533b7d9fe1ef96bd126b977

RESEARCH PRODUCT

Split decomposition A technique to analyze viral evolution

Andreas W. M. DressA Von HaeselerJoaquín Dopazo

subject

EVOLUTIONARY TREESViral quasispeciesBiologyAbstract theoryOVERLAPPING CLUSTERINGAphthovirusMolecular evolutionAnimalsQuantitative Biology::Populations and EvolutionSerotypingCluster analysisGeneticsMultidisciplinaryModels GeneticPhylogenetic treeQUASI-SPECIESHamming distanceBiological EvolutionInvestigation methodsViral evolutionVirusesCattleBiological systemMonte Carlo MethodMathematicsResearch Article

description

A clustering technique allowing a restricted amount of overlapping and based on an abstract theory of coherent decompositions of finite metrics is used to analyze the evolution of foot-and-mouth disease viruses. The emerging picture is compatible with the existence of viral populations with a quasispecies structure and illustrates various forms of evolution of this virus family. In addition, it allows the correlation of these forms with geographic occurrence.

yearjournalcountryeditionlanguage
1993-11-01
10.1073/pnas.90.21.10320http://hdl.handle.net/20.500.12792/1135