Penicillium lanoso-viride AMP dezamināzi atpazīstošo receptoru klāsta detektēšana perifēro asiņu mononukleārajās šūnās

6533b7d9fe1ef96bd126bc43

RESEARCH PRODUCT

Penicillium lanoso-viride AMP dezamināzi atpazīstošo receptoru klāsta detektēšana perifēro asiņu mononukleārajās šūnās

subject

citokīni PRR AMPD TLR4 Bioloģija imūnmodulatori

description

Šajā darbā salīdzināta Penicillium lanoso-viride sintezētās AMPD un citu sēņu izcelsmes imūnmodulatoru un standartvielu iedarbība uz iekaisuma reakcijās iesaistītu molekulu gēnu ekspresiju un sekrēciju asins imūnsistēmas šūnās, un, balstoties uz rezultātos iegūto informāciju, veikta AMPD atpazīstošo PRR analīze. Ar RT-PCR metodi veiktās analīzes uzrāda, ka AMPD stimulētās asins imūnajās šūnās ir paaugstināta iekaisuma citokīnu, kā arī TLR4 signālceļā iesaistīto molekulu gēnu ekspresija, kas norāda uz tās iekaisumu veicinošo ietekmi. Ar receptoru bloķēšanas un ELISA proteīnu koncentrācijas noteikšanas metodes palīdzību noskaidrots, ka AMPD savu imūnmodulatoro darbību asins mononukleārajās šūnās veic caur TLR4

year	journal	country	edition	language
2016-01-01

https://dspace.lu.lv/dspace/handle/7/32205

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