Dabas vielu lipīdu uzkrāšanās un acetilholīnesterāzes inhibīcija cilvēku aknu šūnu līnijā HepG2 in vitro

6533b7d9fe1ef96bd126bc4f

RESEARCH PRODUCT

Dabas vielu lipīdu uzkrāšanās un acetilholīnesterāzes inhibīcija cilvēku aknu šūnu līnijā HepG2 in vitro

subject

aknu steatoze HepG2 Vaccinium ģints acetilholīnesterāzes inhibitori Farmācija

description

Taukaino aknu slimība ir viena no izplatītākajām aknu slimībām attīstītajās valstīs, un tiek iedalīta alkohola un ne-alkohola taukaino aknu slimībā. Taukaino aknu slimībai ir potenciāls progresēt līdz steatohepatītam un cirozei, bet joprojām nav atrastas mērķētas terapijas slimības progresijas palēnināšanai. Maģistra darba mērķis ir pētīt Vaccinium ģints ogu izspaidu ekstraktu iedarbību uz acetilholīna koncentrāciju, acetiholīnesterāzes aktivitāti un lipīdu akumulāciju HepG2 šūnu modelī. Pētījuma rezultāti liecina, ka ogu izspiedu ekstrakti samazina lipīdu akumulāciju šūnās un gan ekstrakti, gan zināmais aknu šūnu funkciju uzlabotājs silimarīns inhibē acetilholīnesterāzes (AChE) aktivitāti. Iegūtie dati apstiprina nesen izvirzīto hipotēzi, ka AChE inhibitori varētu ne tikai darboties CNS, bet arī aizsargāt aknas no citu vielu izraisītiem bojājumiem.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59774

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