SARS-CoV-2 infection in COVID-19 patients in Latvia

6533b7d9fe1ef96bd126bc88

RESEARCH PRODUCT

SARS-CoV-2 infection in COVID-19 patients in Latvia

Samanta Strojeva

subject

SARS-CoV-2 RT-kPĶR COVID-19 ELISA Bioloģija

description

Šī darba ietvaros tika pētīta SARS-CoV-2 infekcija COVID-19 pacientiem Latvijā, raksturojot vīrusa genoma klātbūtni un slodzi vairākos klīniskajos paraugos un antivielas dinamikā. Pētījumā iesaistīti 134 pacienti, kuriem bija detektēts SARS-CoV-2 RNS nazofaringeālājās iztriepēs ar RT-PĶR metodi, pirms hospitalizācijas. Tika ievākti COVID-19 pacientu nazofaringeālās iztriepes, fēces, urīns, asins plazma, PMBC SARS-CoV-2 genoma klātbūtnes un vīrusa slodzes noteikšanai, izmantojot RT-kPĶŖ metodi. Tika ievākti pacientu plazmas paraugi antivielu detektēšanai un raksturošanai dinamikā, izmantojot ELISA metodi. SARS-CoV-2 genoma sekvence visbiežāk tika detektēta nazofaringeālajās iztriepēs (100/134, 74,6%) un fēcēs (76/104, 73,1%). Visaugstākā mediānā slodze tika konstatēta fēču paraugos (14529 [IQR 3224 – 93704] kopijas/ml). IgM antivielu titrs sāk samazināties pēc 12 dienām, un IgG titrs augstā līmenī spēj saglabāties līdz 119 dienām.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59229

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