6533b7d9fe1ef96bd126bd4f

RESEARCH PRODUCT

Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19

Francesco Saverio RagusaLuisa SolimandoCaterina MandalàRoberta MasnataGregorio CiullaStefano CiriminnaFrancesco La BlascaPasquale MansuetoNicola VeroneseMario Barbagallo

subject

Settore MED/09 - Medicina InternaMultidimensional prognostic indexAntibioticInfectious diseasesPrognosis

description

Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens. Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months. Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics. Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.

yearjournalcountryeditionlanguage
2023-03-25
10.1007/s40520-023-02386-yhttps://hdl.handle.net/10447/584897