6533b7d9fe1ef96bd126c003

RESEARCH PRODUCT

Efficiency of Biolistic DNA Vaccination in Experimental Type I Allergy

Joachim MaxeinerVerena RakerAngelika B. Reske-kunzStephan Sudowe

subject

Vaccinationbusiness.industrymedicine.medical_treatmentImmunologyAirway inflammationType i allergyMedicinebusinessGeneCD8Gene gunDNA vaccinationDesensitization (medicine)

description

Gene gun-mediated delivery of allergen-encoding plasmid DNA has been in focus for many years now as being a needle-free alternative to the protein-based desensitization regimen used in specific immunotherapy. Biolistic immunization with the Helios gene gun has proven to be potent in the induction of antigen-specific CD4(+) and CD8(+) T cells. Here we describe biolistic vaccination in experimental mouse models of IgE-mediated type I allergy as well as allergen-induced airway inflammation.

yearjournalcountryeditionlanguage
2012-09-24
https://doi.org/10.1007/978-1-62703-110-3_26