6533b7d9fe1ef96bd126c138
RESEARCH PRODUCT
ChemInform Abstract: Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters.
Gonzalo BlayRuben CantonMarc Montesinos-magranerCarlos VilaM. Carmen MuñozIsabel FernándezJosé R. Pedrosubject
chemistry.chemical_compoundchemistryThioureaIsatinOrganocatalysisEnantioselective synthesisOrganic chemistryGeneral MedicinePhenolsStereocenterdescription
A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99 %) with excellent enantioselectivity (up to 99 % ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-01 | ChemInform |