6533b7d9fe1ef96bd126c252
RESEARCH PRODUCT
Synthesis of pyrido[2,3-d]pyrimidines in the reaction of 6-amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone with chalcones
Braulio InsuastyJairo QuirogaManuel NoguerasA. SanchezHerbert Meiersubject
chemistry.chemical_compoundChalconePyrimidinechemistryOrganic ChemistryLactamSpectroscopyEnoneMedicinal chemistrydescription
6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone (1) reacts in boiling DMF with α,/β-unsaturated ketones 2 yielding the pyrido[2,3-d]pyrimidine systems 5 and 6, respectively. The orientation in the addition process can be determined by nmr measurements, especially by NOE difference spectroscopy. The products do not correspond to a normal Skraup or Doebner-v. Miller synthesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-08-01 |