6533b7d9fe1ef96bd126c2c9

RESEARCH PRODUCT

Short- and long-term effects of vinblastine on the rat adrenal medulla

B. Limmeroth-erwertU. OttenK. LöffelholzR. LindmarU. WolfKlaus Unsicker

subject

medicine.medical_specialtyTime FactorsHistologyChemical PhenomenaVinblastinePathology and Forensic MedicineInternal medicineSingle high doseEnterochromaffin CellsmedicineAnimalsCells Culturedchemistry.chemical_classificationCell BiologyMolecular medicineRatsVinblastineChemistryEnzymemedicine.anatomical_structureEndocrinologychemistryAdrenal MedullaUltrastructureCatecholamineFemaleAdrenal medullamedicine.drug

description

The effects of a single high dose (10mg/kg) of vinblastine (vb) sulfate (“Velbe”, Lilly) on the ultrastructure, catecholamine (CA) content and activity of CA-synthesizing enzymes of the rat adrenal medulla were studied for up to 120h after intravenous injection of the drug.

https://doi.org/10.1007/bf00240102