6533b7d9fe1ef96bd126c328
RESEARCH PRODUCT
Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines.
José R. PedroMelireth HolmquistGonzalo Blaysubject
Nitroaldol reactionChemistryIsatinMetals and AlloysEnantioselective synthesisGeneral ChemistryCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCatalysischemistry.chemical_compoundMaterials ChemistryCeramics and CompositesOrganic chemistryEnantiomerdescription
A highly enantioselective aza-Henry reaction with isatin N-Boc ketimines using a Cu(II)–BOX complex as a catalyst is described. The reaction, which does not require protection of the N1 atom, provides the corresponding nitroamines bearing a quaternary stereocentre with high yields and enantiomeric excesses (up to 99.9%).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-07-08 | Chemical communications (Cambridge, England) |