6533b7d9fe1ef96bd126cd55
RESEARCH PRODUCT
EFFECT OF DELETERIOUS MUTATION-ACCUMULATION ON THE FITNESS OF RNA BACTERIOPHAGE MS2
Santiago F. ElenaMarcos De La PeñaAndrés Moyasubject
GeneticsExperimental evolutionMutation rateBase SequenceGenotypeRNABiologybiology.organism_classificationNegative selectionMutationBacteriophage MS2GeneticsFitness effectsGeneral Agricultural and Biological SciencesDeleterious mutationEcology Evolution Behavior and SystematicsDNA PrimersLevivirusdescription
RNA viruses show the highest mutation rate in nature. It has been extensively demonstrated that, in the absence of purifying selection, RNA viruses accumulate deleterious mutations at a high rate. However, the parameters describing this accumulation are, in general, poorly understood. The present study reports evidences for fitness declines by the accumulation of deleterious mutations in the bacteriophage MS2. We estimated the rate of fitness decline to be as high as 16% per bottleneck transfer. In addition, our results agree with an additive model of fitness effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-04-01 | Evolution |