Sensorimotoro funkciju novērtēšana cilindra un stūra testā pelēm pēc modelēta insulta

6533b7d9fe1ef96bd126d169

RESEARCH PRODUCT

Sensorimotoro funkciju novērtēšana cilindra un stūra testā pelēm pēc modelēta insulta

Zane Lielpētere

subject

stūra tests sensorimotorie traucējumi Farmācija insults peles cilindra tests

description

Insults ir akūta neiroloģiska disfunkcija, kas izraisa neiroloģiskas, sensorimotoras un uzvedības izmaiņas. Lai izprastu insulta patoloģiskos mehānismus un izstrādātu jaunas terapijas, insults tiek modelēts eksperimentāli. Stūra un cilindra uzvedības testus izmanto, lai novērtētu sensorimotorās funkcijas grauzējiem. Maģistra darba mērķis ir izvērtēt cilindra un stūra testa pielietojumu modelēta insulta gadījumā pelēm divu mēnešu periodā. Pētījumā secināts - lai mazinātu peļu pierašanu un neaktivitāti, cilindra un stūra testus ieteicams veikt pārmaiņus, kā arī ne pārāk bieži. Pētījuma sākumā ieteicams veikt pirms operācijas griešanās preferences novērtēšanu. Precīzākai novērtēšanai ieteicams iekļaut pētījumā Naive grupu un vairākus citus uzvedības testus, jo cilindra un stūra testā netika konstatētas specifiskas sensorimotorās izmaiņas. Atslēgas vārdi: insults, sensorimotorie traucējumi, cilindra tests, stūra tests, peles

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54698

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