6533b7d9fe1ef96bd126d31b
RESEARCH PRODUCT
Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates
S. IndelicatoD. BongiornoS. IndelicatoL. DrahosV. Turco LiveriL. TuriàkK. VèkeyL. Ceraulosubject
IonsMesylatesSupramolecular aggregates; MS/MS; Degrees of Freedom effect; fragmentation; activation energySpectrometry Mass Electrospray IonizationAlkanesulfonic AcidsSupramolecular aggregateactivation energyTandem Mass SpectrometryfragmentationSodiumMS/MSDegrees of Freedom effectEnkephalin Leucinedescription
The characteristic collision energy (CCE) to obtain 50% fragmentation of positively and negatively single charged noncovalent clusters has been measured. CCE was found to increase linearly with the degrees of freedom (DoF) of the precursor ion, analogously to that observed for synthetic polymers. This suggests that fragmentation behavior (e.g. energy randomization) in covalent molecules and clusters are similar. Analysis of the slope of CCE with molecular size (DoF) indicates that activation energy of fragmentation of these clusters (loss of a monomer unit) is similar to that of the lowest energy fragmentation of protonated leucine-enkephalin. Positively and negatively charged aggregates behave similarly, but the slope of the CCE versus DoF plot is steeper for positive ions, suggesting that these are more stable than their negative counterparts.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-09-06 |