6533b7d9fe1ef96bd126d321
RESEARCH PRODUCT
Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
Wang GangHallberg JennyCharalampopoulos DimitriosSanahuja Maribel CasasBreyer-kohansal RobabLanghammer ArnulfGranell RaquelVonk Judith MMian AnnemiekOlvera NúriaLaustsen Lisbeth MølgaardRönmark EvaAbellan AliciaAgusti AlvarArshad Syed HasanBergström AnnaBoezen H MarikeBreyer Marie-kathrinBurghuber OttoBolund Anneli CleaCustovic AdnanDevereux GrahamDonaldson Gavin CDuijts LiesbethEsplugues AnaFaner RosaBallester FerranGarcia-aymerich JudithGehring UlrikeHaider SadiaHartl SylviaBackman HelenaHolloway John WKoppelman Gerard HLertxundi AitanaHolmen Turid LingaasLowe LesleyMensink-bout Sara MMurray Clare SRoberts GrahamHedman LinneaSchlünssen ViviSigsgaard TorbenSimpson AngelaSunyer JordiTorrent MatiesTurner StephenVan Den Berge MaartenVermeulen Roel C HVikjord Sigrid Anna AalbergWedzicha Jadwiga AMaitland Van Der Zee Anke HMelén Eriksubject
Folkhälsovetenskap global hälsa socialmedicin och epidemiologiLung FunctionRespiratory Medicine and AllergyOriginal Research ArticlesRwf_140MedicinePublic Health Global Health Social Medicine and Epidemiology109wf_600Lungmedicin och allergiwf_20description
Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score <LLN. Results The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46). Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
year | journal | country | edition | language |
---|---|---|---|---|
2021-12-01 |