6533b7d9fe1ef96bd126d586
RESEARCH PRODUCT
Coumarin derivatives from Pedilanthus tithymaloides as inhibitors of conidial germination in Magnaporthe oryzae
Till OpatzHeidrun AnkeLouis P. SandjoJoachim RheinheimerEckhard ThinesAndrew J. Fostersubject
biologyPedilanthus tithymaloidesChemistryOrganic ChemistryEuphorbiaceaeFungusbiology.organism_classificationCoumarinBiochemistryMagnaporthe oryzaechemistry.chemical_compoundBiochemistryGerminationDrug Discoveryheterocyclic compoundsVolume concentrationdescription
In a screening for inhibitors of infection-related morphogenesis in the rice blast fungus Magnaporthe oryzae, a series of 10 coumarin derivatives were isolated from Pedilanthus tithymaloides (Euphorbiaceae). Seven of these compounds turned out to be known while three represent previously unreported natural products. Their structures were established on the basis of spectroscopic data and X-ray crystallography. Nine out of 10 coumarin derivatives were found to inhibit conidial germination in the phytopathogenic fungus at low concentrations.
year | journal | country | edition | language |
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2012-04-01 | Tetrahedron Letters |