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RESEARCH PRODUCT
Rollimembrin, a novel acetogenin inhibitor of mammalian mitochondrial complex I
M. Carmen GonzálezDiego CortesErnesto EstornellM. Carmen Zafra-poloAlmudena BermejoJosé R. Tormosubject
chemistry.chemical_classificationbiologyStereochemistryOrganic ChemistryClinical BiochemistryAbsolute configurationPharmaceutical ScienceBiological activitybiology.organism_classificationBiochemistryIn vitrochemistry.chemical_compoundEnzymechemistryAnnonaceaeEnzyme inhibitorDrug DiscoveryAcetogeninbiology.proteinMolecular MedicineMolecular BiologyLactonedescription
Abstract Rollimembrin (3), is a new adjacent bis-tetrahydrofuranic acetogenin with a scarce relative configuration, threo/cis/threo/cis/erythro, isolated from Rollinia membranacea seeds. The mechanism of cytotoxic activity, determined by NADH-oxidase experiments, establish that rollimembrin (3) is the most potent inhibitor of mammalian mitochondrial complex I.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-05-01 | Bioorganic & Medicinal Chemistry Letters |