6533b7d9fe1ef96bd126d5fc

RESEARCH PRODUCT

RATIONAL DESIGN OF ANTI-HERPES VIRUS ANTI-METABOLITES

Werner E.g. Müller

subject

Host (biology)Rational designMetabolismBiologyVirologyViruschemistry.chemical_compoundHerpes virusAntigenchemistryInterferonmedicineDNAmedicine.drug

description

Publisher Summary This chapter presents rational design of anti-herpes virus anti-metabolites. Herpesviruses, having DNA as their genetic material, are usually divided into type 1 and type 2 by antigenic differences and by biochemical markers. Herpesviruses are capable to persist in the host they infect, and around 75 % of those persons who were primary infected are afflicted during their lives with recurrent herpetic eruptions. The herpesviruses contain genetic information for the inhibition of the host cell metabolism; but at low multiplicities of infection the infected cells make interferon only. The spectrum of antiviral substances is large. However, only few compounds have been shown to act specifically. The reason for this situation is due to the fact that most of the antitumor and antiviral agents inhibit not only replication of tumor cells or of viruses but also affect metabolism of non-infected cells. Three degrees of selectivity with respect to antiviral agents can be subdivided. These are (1) absolute selectivity; (2) relative selectivity; and (3) no specificity.

yearjournalcountryeditionlanguage
1979-01-01
https://doi.org/10.1016/b978-0-08-024384-9.50031-2