6533b7d9fe1ef96bd126d6d8
RESEARCH PRODUCT
Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae)
Bathelemy NgameniT Armelle MbavengW Ghislain FotsoIbrahim DemirtasJean Na-iyaYeboah SamuelThomas EfferthPatrick Ango YvesT Bonaventure NgadjuiVictor Kuetesubject
chemistry.chemical_classificationStem barkbiologyTraditional medicine010405 organic chemistryChemistryOrganic ChemistryAcaciaPlant ScienceFabaceaebiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistrychemistry.chemical_compoundCytotoxic T cell3-O-methyl-D-chiro-inositolOleananeTriterpenoid saponindescription
The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue 8, compound 1 as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound 1 and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-06-25 |