6533b7dafe1ef96bd126d932

RESEARCH PRODUCT

Natural Inhibitors of P-glycoprotein in AcuteMyeloid Leukemia

Manuela LabbozzettaPaola PomaMonica Notarbartolo

subject

Inorganic Chemistrymultidrug resistanceOrganic ChemistrySettore BIO/14 - FarmacologiaGeneral Medicinenatural substancesPhysical and Theoretical Chemistryacute myeloid leukemiaP-glycoproteinMolecular BiologySpectroscopyCatalysisComputer Science Applications

description

Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms, and it is often caused by the overexpression of efflux pumps, the most important of which is P-glycoprotein (P-gp). This mini-review aims to examine the advantages of using natural substances as P-gp inhibitors, focusing on four molecules: phytol, curcumin, lupeol, and heptacosane, and their mechanism of action in AML.

yearjournalcountryeditionlanguage
2023-02-18
10.3390/ijms24044140https://hdl.handle.net/10447/590696