6533b7dafe1ef96bd126d938
RESEARCH PRODUCT
B cell immunosenescence in the elderly and in centenarians.
Giuseppina CandoreDomenico LioGiuseppina Colonna-romanoSalvatore VitelloCalogero CarusoAlessandra AquinoMatteo Bulatisubject
Settore MED/04 - Patologia GeneraleAged 80 and overAgingB-LymphocytesLymphocyteT cellNaive B cellImmunosenescenceBiologymedicine.anatomical_structureImmune systemAntigenImmunologymedicineHumanselderly chronic antigen exposure senescence of B cellsGeriatrics and GerontologyCell agingB cellCellular SenescenceAgeddescription
The elderly suffer from an increased susceptibility to infectious disease and cancer. Aging of the immune system contributes to this state of affairs due to immunosenescence. Because repeated intermittent or chronic antigen exposure may lead to lymphocyte clonal exhaustion, chronic antigenic stress plays a part in the compromised immunity of the elderly, who have accumulated a lifetime's exposure to infectious agents, autoantigens, and cancer antigens. Literature on immunosenescence has focused mainly on T cell impairment, but B cell compartment is also affected. The age-dependent B cell changes documented by the present review indicate that advanced age per se is a condition characterized by lack of B clonotypic immune response to new extracellular pathogens. In any event, data are suggesting that the loss of naive B cells could represent a hallmark of immunosenescence and could provide a biomarker possibly related to the life span of humans and potentially useful for the evaluation of anti-aging treatment. Since information on the senescence of B cells is of obvious interest, further studies are necessary to confirm these suggestions as well as to extend the number of markers used to characterize the cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-04-28 | Rejuvenation research |