6533b7dafe1ef96bd126e2c9
RESEARCH PRODUCT
Fine specificity and cytolytic activity of continuously growing alloreactive cytotoxic T lymphocyte clones.
Martin RöllinghoffHermann WagnerR. Schawallersubject
Cytotoxicity ImmunologicT-LymphocytesImmunologyCellchemical and pharmacologic phenomenaCell LineMiceAntibody SpecificitymedicineCytotoxic T cellAnimalsAntigens ViralMice Inbred BALB CChemistryEffectorH-2 Antigenshemic and immune systemsGeneral MedicineVirologyMolecular biologyClone CellsCTL*Cytolysismedicine.anatomical_structureLytic cycleCell cultureMonoclonalMice Inbred CBALymphocyte Culture Test MixedSpleendescription
The role of Lyt 1+ T-cell-derived secondard CTL inducing factor allowed the cloning of alloreactive cytotoxic T lymphocytes (CTL) by the limiting dilution approach. Several monoclonal cell lines were established in vitro. The lytic activity of some of the cell lines exceeded that of CTL from bulk cultures; that is, 50% of the target cells were lysed at an effector to target cell ratio of 0.04:1. The fine specificity of individual CTL clones is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-04-01 | Scandinavian journal of immunology |