6533b7dafe1ef96bd126e7c0

RESEARCH PRODUCT

Catalytic Asymmetric Reactions Involving the Seven-Membered Cyclic Imine Moieties Present in Dibenzo[b,f][1,4]oxazepines

Lode De MunckCarlos Vila DescalsJosé Ramón Pedro

subject

CatàlisiReaccions químiques

description

The dibenzo[b,f][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[b,f][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven-membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.

yearjournalcountryeditionlanguage
2018-01-01
10.1002/ejoc.201701279https://doi.org/10.1002/ejoc.201701279