6533b7dafe1ef96bd126ed2a
RESEARCH PRODUCT
First Protection of a Wide-Rim Tetraamino Calix[4]arene in Opposite Positions
Yuliya RudzevichVolker BöhmerValentyn RudzevichDieter Schollmeyersubject
AcylationTrityl chloridechemistry.chemical_compoundchemistryGroup (periodic table)Yield (chemistry)Organic ChemistryPhysical and Theoretical ChemistryBiochemistryMedicinal chemistryDerivative (chemistry)Acyl groupdescription
The importance of tetraamino calix[4]arenes as starting materials is distinctly increased by the first versatile protective group for opposite amino functions. Reaction with trityl chloride leads to the 1,3-dialkylated derivative easily isolated in 34% yield; after a first acylation of the remaining amino groups, the trityl residues can be removed by TFA to introduce a second acyl group. [reaction: see text]
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-02-13 | Organic Letters |