Chronic consumption of an inositol-enriched carob extract improves postprandial glycaemia and insulin sensitivity in healthy subjects: A randomized controlled trial

6533b7dafe1ef96bd126f71c

RESEARCH PRODUCT

Chronic consumption of an inositol-enriched carob extract improves postprandial glycaemia and insulin sensitivity in healthy subjects: A randomized controlled trial

Milagros Rocha Rosa Falcón Victor M. Victor Antonio Hernández-mijares Nuria Monzó Silvia Veses Celia Bañuls Susana Rovira-llopis

subject

Blood Glucose Male Apolipoprotein B medicine.medical_treatment 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine law.invention chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Continuous glucose monitoring system Healthy subjects 030212 general & internal medicine Hypolipidemic Agents Nutrition and Dietetics biology Area under the curve Fabaceae Postprandial Period Postprandial LDL particle size Seeds Female Inositols Adult medicine.medical_specialty Carob pod extract Monitoring Ambulatory Hyperlipidemias 03 medical and health sciences Double-Blind Method Internal medicine medicine Humans Hypoglycemic Agents Particle Size Pinitol Plant Extracts business.industry Pinitol Insulin Metabolism Endocrinology Lipoproteins IDL chemistry Spain Fruit Hyperglycemia Dietary Supplements biology.protein Insulin Resistance business Inositol Lipoprotein

description

Background & aims: Inositols are thought to be mediators of the insulin signalling pathway. We assessed the effects of inositols on glycaemic control in fasting and postprandial states and evaluated lipoprotein profile and LDL particle size in healthy population. Methods: A 12-week double-blind clinical trial was performed with forty healthy subjects administered either an inositol-enriched beverage (IEB) -containing 2.23 g of inositols in 250 ml- or a sucrose-sweetened beverage (SB) twice a day. Anthropometric measurements, fasting glucose levels, insulin and HOMA-IR index, lipoprotein profile and postprandial glucose concentrations (measured using the continuous glucose monitoring system (CGMS)) were recorded throughout the intervention period. Results: Following the 12-week trial subjects receiving the IEB exhibited a significant decrease in insulin, HOMA-IR and Apo B and an increase in LDL particle size, whereas the SB group showed increases in BMI and fasting glucose concentration. Analysis of postprandial glucose levels at breakfast, lunch and dinner revealed a mean reduction of glucose of approximate to 14% and a significant reduction in the area under the curve at 24 h after consumption of the IEB. Conclusions: Our results show that chronic IEB supplementation induces a significant improvement in carbohydrated metabolism parameters in healthy subjects. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

year	journal	country	edition	language
2016-01-01	Clinical Nutrition

https://doi.org/10.1016/j.clnu.2015.05.005