Maizes rauga Saccharomyces cerevisiae purīna auksotrofijas ietekme uz mitohondriju metabolismu

6533b7dbfe1ef96bd126f9cc

RESEARCH PRODUCT

Maizes rauga Saccharomyces cerevisiae purīna auksotrofijas ietekme uz mitohondriju metabolismu

subject

mitohondriji Krebsa cikls purīnu auksotrofija šūnu elpošana Bioloģija

description

Darba ietvaros pētīta purīnu biosintēzes ceļa saistība ar mitohondrionālo metabolismu. Veikta purīnu biosintēzes mutantu kultivēšana dažādu oglekļa avotu, kā arī mitohondrionālo procesu inhibitoru klātbūtnē gan šķidrajā barotnē, gan uz agara platēm. Tāpat šajā darbā mērīta trīs Krebsa cikla enzīmu aktivitāte. Novērots, ka pielāgošanās ātrums fermentatīvo substrātu maiņas gadījumā ir atkarīgs no iepriekšējiem augšanas apstākļiem - badinātām purīnu auksotrofu šūnu kultūrām novērota augstāka pielāgotība nekā pilnajā barotnē augušajām. Iegūtie rezultāti norāda, ka purīnu de novo sintēzes ceļa mutācijas ietekmē mitohondriju metabolismu. ade2 un ade6 mutantiem novērotas izmaiņas oglekļa metabolismā, kas nav raksturīgas citiem auksotrofiem, bet ade16ade17 atgādina petite celmus.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59218

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