Adult-onset Still's disease with elderly onset: results from a multicentre study

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RESEARCH PRODUCT

Adult-onset Still's disease with elderly onset: results from a multicentre study

Ilenia Di Cola Claudia Di Muzio Alessandro Conforti Daniela Iacono Ilenia Pantano Gelsomina Rozza Silvia Rossi Ludovico De Stefano Antonio Vitale Francesco Caso Luisa Costa Marcella Prete Luca Navarini Annamaria Iagnocco Fabiola Atzeni Giuliana Guggino Federico Perosa Luca Cantarini Bruno Frediani Serena Bugatti Carlomaurizio Montecucco Francesco Ciccia Roberto Giacomelli Paola Cipriani Piero Ruscitti

subject

Lung Diseases Adult-Onset Adult comorbiditie Immunology adult-onset Still's disease comorbidities Lung Disease serositis adult-onset Still's disease; aging; serositis; parenchymal lung disease; comorbidities; Adult; Aged; Humans; Middle Aged; Retrospective Studies; Lung Diseases; Macrophage Activation Syndrome; Serositis; Still's Disease Adult-Onset Rheumatology Retrospective Studie Immunology and Allergy Humans Retrospective Studies Aged comorbidities.Serositi Macrophage Activation Syndrome aging Middle Aged Still's Disease adult-onset Still's disease; aging; serositis; parenchymal lung disease; comorbidities Still's Disease Adult-Onset parenchymal lung disease Human

description

Objective In this study, we aimed to describe the clinical characteristics, life-threatening complications occurrence, and mortality of adult-onset Still's disease (AOSD) patients with elderly onset. Methods A multicentre retrospective study of prospectively followed-up AOSD patients included in Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort was performed. Results Out of 221 assessed patients, 37 (16.7%) had an onset of the disease aged over 60 years. When compared with younger patients, these were characterised by a higher prevalence of pericarditis (p=0.008), comorbidities (p < 0.0001), and mortality (p=0.023). Age predicted the presence of serositis in both univariate (HR: 1.02, 95%CI: 1.01-1.03, p=0.007) and multivariate analyses (HR: 1.02, 95%CI: 1.01-1.04, p=0.007). Age was also a significant predictor of parenchymal lung disease in both univariate (HR: 1.03, 95%CI: 1.01-1.05, p=0.017) and multivariate analyses (HR: 1.03, 95%CI: 1.00-1.05, p=0.048). Furthermore, age resulted to be a negative predictor of polycyclic pattern only in univariate analysis (HR: 0.99, 95%CI: 0.97-1.00, p=0.048). Finally, age significantly predicted the mortality in both univariate (HR: 1.03, 95%CI: 1.00-1.06, p=0.034) and multivariate analyses (HR: 1.05, 95%CI: 1.01-1.08, p=0.012). Conclusion Clinical features of AOSD patients in the elderly were described in our cohort. Although the main clinical characteristics were similar comparing older and younger patients, patients aged over 60 years at disease onset were characterised by an increased prevalence of serositis, comorbidities, mostly cardiometabolic, and a higher mortality rate. Age predicted the presence of parenchymal lung disease and mortality, and it could be considered a negative prognostic factor in AOSD.

year	journal	country	edition	language
2021-12-21

https://hdl.handle.net/11697/197773