Phylostratic Shift of Whole-Genome Duplications in Normal Mammalian Tissues towards Unicellularity Is Driven by Developmental Bivalent Genes and Reveals a Link to Cancer

6533b7dbfe1ef96bd1270a41

RESEARCH PRODUCT

Phylostratic Shift of Whole-Genome Duplications in Normal Mammalian Tissues towards Unicellularity Is Driven by Developmental Bivalent Genes and Reveals a Link to Cancer

Alexander E. Vinogradov Jekaterina Erenpreisa Alessandro Giuliani Olga V. Anatskaya Ninel M. Vainshelbaum Ninel M. Vainshelbaum

subject

Carcinogenesis Circadian clock Antineoplastic Agents Biology Genome Article Catalysis Bivalent (genetics)Epigenesis Genetic lcsh:Chemistry Proto-Oncogene Proteins c-myc Inorganic Chemistry Transcriptome Mice Polyploid Gene Duplication Neoplasms Protein Interaction Mapping Animals Humans cancer Epigenetics Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Gene polyploidy bivalent genes Spectroscopy Genetics Genome Ploidies Circadian Rhythm Signaling Peptides and Proteins Organic Chemistry early multicellularity viral-origin oncogenes Oncogenes General Medicine embryonality Phenotype Neoplasm Proteins unicellularity Computer Science Applications Gene Expression Regulation Neoplastic lcsh:Biology (General)lcsh:QD1-999 Drug Resistance Neoplasm Metabolic Networks and Pathways

description

Tumours were recently revealed to undergo a phylostratic and phenotypic shift to unicellularity. As well, aggressive tumours are characterized by an increased proportion of polyploid cells. In order to investigate a possible shared causation of these two features, we performed a comparative phylostratigraphic analysis of ploidy-related genes, obtained from transcriptomic data for polyploid and diploid human and mouse tissues using pairwise cross-species transcriptome comparison and principal component analysis. Our results indicate that polyploidy shifts the evolutionary age balance of the expressed genes from the late metazoan phylostrata towards the upregulation of unicellular and early metazoan phylostrata. The up-regulation of unicellular metabolic and drug-resistance pathways and the downregulation of pathways related to circadian clock were identified. This evolutionary shift was associated with the enrichment of ploidy with bivalent genes (p &lt

year	journal	country	edition	language
2020-11-19	International Journal of Molecular Sciences

https://doi.org/10.3390/ijms21228759