6533b7dbfe1ef96bd1270a62

RESEARCH PRODUCT

Sample preparation strategies for the determination of psychoactive substances in biological fluids

Sergio ArmentaMiguel De La GuardiaFrancesc A. Esteve-turrillas

subject

SorbentLiquid Phase MicroextractionLiquid-Liquid ExtractionClinical Chemistry Tests010402 general chemistry01 natural sciencesBiochemistrySpecimen HandlingAnalytical ChemistryMatrix (chemical analysis)Liquid chromatography–mass spectrometryBiological fluidsHumansSample preparationSolid phase extractionSalivaSolid Phase MicroextractionChromatographyPsychotropic DrugsChromatographyChemistrySolid Phase Extraction010401 analytical chemistryOrganic ChemistryExtraction (chemistry)General MedicineBody Fluids0104 chemical sciencesAnalytical procedures

description

This review focuses on the existing analytical procedures for the determination of new psychoactive substances (NPS) in biological fluids by chromatographic methods. Direct analysis of samples is scarcely employed and most proposed methodologies include a sample pre-treatment in order to remove matrix interferents and, in some cases, pre-concentrate extracts. Current extraction methods for NPS determination in plasma/serum, urine, and oral fluids have been widely discussed, such as liquid-liquid, solid-phase, and micro extraction approaches, highlighting the advantages and drawbacks of the proposed extraction methodologies. Regarding microextraction approaches, techniques like microextraction by packed sorbent, solid-phase microextraction, miniaturized solid phase extraction, and dispersive liquid-liquid extraction have been proposed for NPS determination in biological fluids with reliable analytical results.

yearjournalcountryeditionlanguage
2020-12-01Journal of Chromatography A
https://doi.org/10.1016/j.chroma.2020.461615