6533b7dbfe1ef96bd1270acd
RESEARCH PRODUCT
Synthesis of potentially anti-inflammatory IPL576,092-contignasterol and IPL576,092-manoalide hybrids
Carmela Della MonicaFrancesco De RiccardisIrene IzzoAgostino CasapulloElvira AvalloneMaria Amigósubject
Contignasterolmedicine.drug_classStereochemistryOrganic ChemistryBiochemistryHigh yieldingCombinatorial chemistryAnti-inflammatoryManoalidechemistry.chemical_compoundchemistryDrug DiscoverymedicineStereoselectivitydescription
The synthesis of two potentially anti-inflammatory steroidal hybrid compounds has been accomplished through a 16- and 17-step sequence, respectively, starting from commercially available androst-5-en-3β-ol-17-one. The synthetic strategies are based both on stereoselective side chains elaboration and high yielding functional group transformations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-06-01 | Tetrahedron |