6533b7dbfe1ef96bd1270b1e

RESEARCH PRODUCT

Metformin: Sex/Gender Differences in Its Uses and Effects-Narrative Review

Ioannis IliasRizzo ManfrediLina Zabuliene

subject

Maleendocrine system diseasesGeneral MedicineMetformin gender insulin resistanceMetforminCOVID-19 Drug TreatmentSex FactorsDiabetes Mellitus Type 2Pregnancygender ; insulin resistance ; metforminHumansHypoglycemic AgentsFemalePolycystic Ovary Syndrome

description

Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.

yearjournalcountryeditionlanguage
2022-03-16
10.3390/medicina58030430https://hdl.handle.net/10447/584537