(Strept)avidin as host for biotinylated coordination complexes: stability, chiral discrimination, and cooperativity

6533b7dbfe1ef96bd1270b41

RESEARCH PRODUCT

(Strept)avidin as host for biotinylated coordination complexes: stability, chiral discrimination, and cooperativity

Thomas R. Ward Sylwester Mazurek Julieta Gradinaru Carl Wilhelm Schlaepfer Marjana Novic Untung E. Rusbandi Michel Meyer Klaus Bernauer Andreas Loosli

subject

Streptavidin Circular dichroism Protein Conformation Stereochemistry Biotin chemistry.chemical_element Cooperativity 010402 general chemistry 01 natural sciences Inorganic Chemistry Structure-Activity Relationship Bipyridine chemistry.chemical_compound 2 2'-Dipyridyl Bacterial Proteins Biotin Coordination Complexes Biotinylation [CHIM.COOR]Chemical Sciences/Coordination chemistry Physical and Theoretical Chemistry ComputingMilieux_MISCELLANEOUS Molecular Structure biology 010405 organic chemistry [ CHIM.COOR ] Chemical Sciences/Coordination chemistry Avidin Protein Structure Tertiary 0104 chemical sciences Ruthenium [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry Crystallography chemistry Biotinylation [ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistry biology.protein Streptavidin Avidin

description

Incorporation of a biotinylated ruthenium tris(bipyridine) [Ru(bpy)₂(Biot-bpy)]²⁺ (1) in either avidin or streptavidin-(strept)avidin-can be conveniently followed by circular dichroism spectroscopy. To determine the stepwise association constants, cooperativity, and chiral discrimination properties, diastereopure (Λ and δ)-1 species were synthesized and incorporated in tetrameric (strept)avidin to afford (δ-[Ru(bpy)₂(Biot-bpy)]²⁺)x⊂avidin, (Λ- [Ru(bpy)₂(Biot-bpy)]²⁺)x⊂avidin, (δ-[Ru(bpy)₂(Biot- bpy)]²⁺)x⊂streptavidin, and (Λ-[Ru(bpy)₂(Biot-bpy)]²⁺) x⊂streptavidin (x = 1-4) For these four systems, the overall stability constants are log β₄ = 28.6, 30.3, 36.2, and 36.4, respectively. Critical analysis of the CD titrations data suggests a strong cooperativity between the first and the second binding event (x = 1, 2) and a pronounced difference in affinity between avidin and streptavidin for the dicationic guest 1 as well as modest enantiodiscrimination properties with avidin as host.

year	journal	country	edition	language
2005-12-24

https://hal.archives-ouvertes.fr/hal-00458970

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