Rezistences pret antibakteriālajiem līdzekļiem un bioplēvju veidošanās noteikšana no ķirurģiskā materiālā izolētiem Staphylococcus epidermidis celmiem

6533b7dbfe1ef96bd1270f0a

RESEARCH PRODUCT

Rezistences pret antibakteriālajiem līdzekļiem un bioplēvju veidošanās noteikšana no ķirurģiskā materiālā izolētiem Staphylococcus epidermidis celmiem

subject

MRSE Staphylococcus epidermidis biofilmas Farmācija Antibakteriālā rezistence sonikācija

description

Staphylococcus epidermidis ir komensāls oportūnists, kas ir plaši sastopams kā daļa no ādas normālās mikrofloras. Bieži tas kā kontaminants nokļūst uz protēžu vai katetru virsmas un veicina noturīgu infekciju attīstību. Pateicoties S. epidermids biofilmu veidojošai īpašībai 80% grūti ārstējamu infekciju gadījumos novērojama to klātbūtne. Meticilīna rezistence ir plaši izplatīta pateicoties mecA gēna klātbūtnei. Svarīgi izprast rezistences mehānismus un biofilmu dabu, lai tās varētu laboratoriski noteikt un atrastu veidu, kā cīnīties ar sarežģītām infekcijām. Darba ietvaros noteikts, ka klīniskajos izolātos novērojama izteikta rezistence pret ciprofloksacīnu, klindamicīnu, eritromicīnu, cefoksitīnu un trimetromprimu/sulfametaksazolu. Novērota izteikta mikroorganisma tendence veidot biofilmas, kā arī plaša mecA klātbūtne. Pilnīga jutība novērota tikai vankomicīnam.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54691

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