ChemInform Abstract: Synthesis of New 3-(3-Phenyl-isoxazol-5-yl) or 3-[(3-Phenyl-isoxazol-5-yl)amino] Substituted 4(3H)-Quinazolinone Derivatives with Antineoplastic Activity.

6533b7dbfe1ef96bd1271323

RESEARCH PRODUCT

ChemInform Abstract: Synthesis of New 3-(3-Phenyl-isoxazol-5-yl) or 3-[(3-Phenyl-isoxazol-5-yl)amino] Substituted 4(3H)-Quinazolinone Derivatives with Antineoplastic Activity.

Fulvio Plescia Benedetta Maggio Demetrio Raffa Giuseppe Daidone Domenico Schillaci

subject

chemistry.chemical_compound chemistry Cell culture Stereochemistry Ic50 values General Medicine Quinazolinone In vitro

description

A novel series of 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)amino] substituted 4(3H)-quinazolinone derivatives was synthesized. The compounds were tested for their antineoplastic activity in vitro against Raji (human Burkitt limphoma). K-562 (human chronic myelogeneous leukemia) and U937 (human histiocytic limphoma) cell lines. The most active quinazolinones showed IC50 values in the range 16-30 microM.

year	journal	country	edition	language
2010-06-14	ChemInform

https://doi.org/10.1002/chin.199931194

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