6533b7dbfe1ef96bd1271341

RESEARCH PRODUCT

Tumor Vascularity, Hypoxia, and Malignant Progression in Solid Neoplasms

W. WeikelBillur AralMichael HöckelKarlheinz SchlengerU. Schäffer

subject

Tumor hypoxiabusiness.industryCell growthAngiogenesisCancer researchMedicineNeoplastic cellDiseaseTumor OxygenationMalignant progressionHypoxia (medical)medicine.symptombusiness

description

Malignant progression designates the biologic process which transforms a phenotypically normal cell fixed and cooperating within a tissue into a disseminated therapy-resistant lethal disease. In clinical terms this process consists of three major steps (Fig. 1): () the transition from regulated to deregulated cell proliferation, () the emerging ability of the neoplastic cell collectives to induce angiogenesis and to invade other tissues, () the development of metastases and of resistance towards anti-tumor therapies.

yearjournalcountryeditionlanguage
1998-01-01
https://doi.org/10.1007/978-1-4757-9185-3_38