6533b7dbfe1ef96bd127142b
RESEARCH PRODUCT
Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide Delivery.
Lutz NuhnNadine LeberRudolf Zentelsubject
Liver CirrhosisSmall interfering RNAPolymers and PlasticsLiver fibrosisNanoparticleEpitopes T-LymphocyteBioengineeringNanotechnology02 engineering and technology010402 general chemistry01 natural sciencesBiomaterialsImmunomodulationMiceIn vivoCationsMaterials ChemistryAnimalsHumansRNA Small InterferingDrug CarriersOligonucleotideChemistryMucin-1Cationic polymerizationHydrogels021001 nanoscience & nanotechnologyIn vitroImmunity Innate0104 chemical sciencesCpG siteOligodeoxyribonucleotidesMethacrylatesNanoparticles0210 nano-technologyBiotechnologydescription
Short pharmaceutical active oligonucleotides such as small interfering RNA (siRNA) or cytidine-phosphate-guanosine (CpG) are considered as powerful therapeutic alternatives, especially to medicate hard-to-treat diseases (e.g., liver fibrosis or cancer). Unfortunately, these molecules are equipped with poor pharmacokinetic properties that prevent them from translation. Well-defined nanosized carriers can provide opportunities to optimize their delivery and guide them to their site of action. Among several concepts, this Feature Article focuses on cationic nanohydrogel particles as a universal delivery system for small anionic molecules including siRNA and CpG. Cationic nanohydrogels are derived from preaggregated precursor block copolymers, which are further cross-linked to obtain well-defined nanoparticles of tunable sizes and with (degradable) cationic cores. Novel opportunities for oligonucleotide delivery in vitro and in vivo with respect to liver fibrosis therapies will be highlighted as well as perspectives toward modulating the immune system. In general, the approach of covalently stabilized cationic carrier systems can contribute to find advanced oligonucleotide therapeutics.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-03-11 | Macromolecular bioscience |