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RESEARCH PRODUCT
Osteoprotegerin: multiple partners for multiple functions.
Dominique HeymannMarc Baud'huinMarc Baud'huinStéphane TéletchéaStéphane TéletchéaMarie-françoise HeymannLaurence DuplombCarmen Ruiz-velascoCarmen Ruiz-velascoMike MaillassonFrancois LamoureuxFrancois LamoureuxFrançoise Rédinisubject
musculoskeletal diseasesCell SurvivalEndocrinology Diabetes and MetabolismImmunologyOsteoclastsGeneral Biochemistry Genetics and Molecular BiologyTNF-Related Apoptosis-Inducing LigandOsteoprotegerinImmunology and AllergyAnimalsHumansCell adhesionReceptorCell ProliferationbiologyActivator (genetics)Cell growthChemistryRANK LigandOsteoprotegerinCell DifferentiationIn vitroCell biologyBiochemistryRANKLbiology.proteinDecoydescription
Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the osteoclasts, thus inhibiting their differentiation. However, there are additional ligands of OPG that confer various biological functions. OPG can promote cell survival, cell proliferation and facilitates migration by binding TNF-related apoptosis inducing ligand (TRAIL), glycosaminoglycans or proteoglycans. A large number of in vitro, pre-clinical and clinical studies provide evidences of OPG involvement in vascular, bone, immune and tumor biology. This review describes an overview of the different OPG ligands regulating its biological functions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-10-01 | Cytokinegrowth factor reviews |