6533b7dcfe1ef96bd1271679

RESEARCH PRODUCT

Design and fabrication of an acoustic micromixer for biological media activation

subject

description

International audience; The bioassay of infinitesimal quantities of protein markers in biological samples is the way to early cancer detection. However, this detection can be limited by the diffusion of these macromolecules (analytes) from the bulk to the sensor chip (surface of ligands). Here, we propose a new method to overcome this drawback by the activation of the biological media during the detection step. The principle consists in using ultrasonic vibrations in order to disrupt the equilibrium states of such biomolecular reactions and performing simultaneous detection inside an acoustic micromixer. Technological realization and initial characterizations of the device have been performed and are presented in this work. Moreover, the capacity of our system to enhance the biosensors performances was studied and validated through a biological model related to breast cancer.