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RESEARCH PRODUCT
An Alginate/Cyclodextrin Spray Drying Matrix to Improve Shelf Life and Antioxidant Efficiency of a Blood Orange By-Product Extract Rich in Polyphenols: MMPs Inhibition and Antiglycation Activity in Dysmetabolic Diseases
Virgilio GiannoneVirgilio GiannoneGiovanni PuglisiLucia CrascìPaolo RapisardaSimona FabroniMaria Rosaria LauroAnna Maria PanicoFrancesca SansoneGabriele Ballistrerisubject
AgingAntioxidantArticle SubjectAlginatesmedicine.medical_treatmentspray-dried alginate/β-cyclodextrin microsystemsCitrus by-product02 engineering and technologyOrange (colour)Matrix Metalloproteinase InhibitorsShelf lifeBiochemistryAGEsAntioxidants0404 agricultural biotechnologyGlucuronic Acidmedicinelcsh:QH573-671chemistry.chemical_classificationChromatographyCyclodextrinChemistrylcsh:CytologyPlant Extractspolyphenols and anthocyanins characterizationHexuronic AcidsPolyphenols04 agricultural and veterinary sciencesCell BiologyGeneral MedicineCitrus by-product; polyphenols and anthocyanins characterization; spray-dried alginate/β-cyclodextrin microsystems; MMPs; AGEs.021001 nanoscience & nanotechnology040401 food scienceFluid extractPolyphenolSpray dryingBioflavonoidMMPs0210 nano-technologyResearch ArticleCitrus sinensisdescription
Alginate and β-cyclodextrin were used to produce easily dosable and spray-dried microsystems of a dried blood orange extract with antidysmetabolic properties, obtained from a by-product fluid extract. The spray-dried applied conditions were able to obtain a concentrate dried extract without the loss of AOA and with TPC and TMA values of 35–40% higher than that of the starting material. They were also effective in producing microparticles with 80–100% of encapsulation efficiency. The 2% sodium alginate was capable of improving the extract shelf life, while the beta-cyclodextrin (1 : 1 molar ratio with dried extract) prolonged the extract antioxidant efficiency by 6 hours. The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-01 | Oxidative Medicine and Cellular Longevity |