6533b7dcfe1ef96bd12725b0

RESEARCH PRODUCT

Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

Alessio TerenziHugo GattusoAngelo SpinelloBernhard K. KepplerChristophe ChipotFrançois DehezGiampaolo BaroneAntonio Monari

subject

anticancer drugslcsh:Therapeutics. PharmacologySettore CHIM/03 - Chimica Generale E Inorganicalcsh:RM1-950All atom molecular dynamicall atom molecular dynamics[CHIM]Chemical Sciencesheterocyclic compoundsAnticancer drugguanine quadruplexesArticleComputingMilieux_MISCELLANEOUScircular dichroism

description

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences&mdash

yearjournalcountryeditionlanguage
2019-10-01
10.3390/antiox8100472https://doi.org/10.3390/antiox8100472