6533b7dcfe1ef96bd12727ab

RESEARCH PRODUCT

ChemInform Abstract: 1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD), 7-Methyl-TBD (MTBD) and the Polymer-Supported TBD (P-TBD): Three Efficient Catalysts for the Nitroaldol (Henry) Reaction and for the Addition of Dialkyl Phosphites to Unsaturated Systems.

Riccardo BaruchelloFrancesco Paolo InvidiataDaniele SimoniRiccardo RondaninMassimo Morini

subject

chemistry.chemical_compoundAddition reactionNitroaldol reactionchemistryNucleophileOrganic chemistryGeneral MedicineDerivative (chemistry)Ene reactionPolymer supportedCatalysis

description

Abstract The 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and its 7-methyl derivative (MTBD) have been proven to be of great synthetic utility as catalysts in the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to a variety of carbonyl compounds. The catalysts were in many cases superior to the parent tetramethylguanidine (TMG). In general the reaction proceeds in a few minutes at 0°C. The polymer-supported-TBD (P-TBD) was also proven to be an efficient promoter of the above cited nucleophilic additions.

yearjournalcountryeditionlanguage
2010-06-07ChemInform
https://doi.org/10.1002/chin.200025049