Zileņu izspiedu ekstrakta pretiekaisuma efekti in vitro

6533b7dcfe1ef96bd1272de1

RESEARCH PRODUCT

Zileņu izspiedu ekstrakta pretiekaisuma efekti in vitro

subject

Vaccinium spp. ogu ekstrakti polifenoli IC50 COX – 1 Farmācija COX – 2 LOX - 5

description

Savvaļas ogu bioaktīvi fitoķīmiski savienojumi kopā spēj uzrādīt virkni bioloģisko aktivitāšu, ietekmējot cilvēku veselību. Veselību ietekmējošās bioloģiskās aktivitātes galvenokārt attiecināmas uz sastāvā esošajiem polifenoliem, kuriem piemīt antioksidantu, pretiekaisuma un pretmikrobu īpašības. Darba mērķis ir pētīt zileņu izspiedu ekstrakta pretiekaisuma efektus in vitro. Pētījumā tika pētīta zileņu izspiedu ekstrakta ietekme uz iekaisuma procesos iesaistīto enzīmu - ksantīnoksidāzes, lipoksigenāžu 5 un 15 (LOX-5 un LOX-15) un ciklooksigenāzes 1 (COX-1) aktivitāti, izmantojot fluorimetriskās un kolorimetriskās metodes. Rezultāti liecina, ka zileņu izspiedu ekstrakts inhibē COX-1, LOX-5 un ksantīnoksidāzes aktivitāti, bet neietekmē LOX-15 aktivitāti. Secinājums ir, ka ekstraktam piemīt pretiekaisuma īpašības in vitro testos un visspēcīgāk izpaužas ksantīnoksidāzes inhibīcija.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/51274

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